Abstract
Julio Fernández Pardal, Antonio R. Granata and Avelino Barrio. Influence of calcium on 3H-noradrenaline release by Latrodectus antheratus (black widow spider) venom gland extract in arterial tissues of the rat. Toxicon 17, 455–465, 1979.— Latrodectus antheratus spider venom gland extract induced the release of 3H-noradrenaline ( 3H-NA) from isolated mesenteric arteries and the tail artery of the rat, which was accompanied by a rise in the perfusion pressure. Both phenomena were calcium-dependent. In the mesenteric arteries both effects were blocked by perfusion of the preparation with calcium-free solution. However, in the tail artery they were only partially antagonized (74% decrease). This data coincides with that obtained in the presence of agents that block the entrance of calcium into the nerve endings (Co 2+, Mn 2+, K +). An increase in the calcium concentration of the perfusion medium above normal led to a decrease of the transmitter release by the venom bland extract. Furthermore these results are in agreement with those obtained with drugs that facilitate calcium entrance (tetraethylammonium, Ba 2+). Our results are compatible with a depolarization-like effect of the venom gland extract.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
