Abstract
In order to confirm the effect of calcium-binding protein in bovine milk (mCaBP) on intestinal calcium absorption, calcium transport was measured in the presence and the absence of exogenous mCaBP using the everted gut sac method and ligated-loop method. Exogenous mCaBP significantly stimulated the absorption of calcium in the lower ileum, but not in the duodenum in both vitamin D-deficient and normal rats only as determined by the ligated-loop method. These observations suggest that the stimulating mechanism of exogenous mCaBP for calcium transport is clearly different from that of vitamin D-dependent CaBP in intestinal epithelial cells, and that calcium transport in the lower intestine is effectively stimulated in the presence of both exogenous mCaBP and vitamin D-dependent CaBP. These results are tempting to suggest that mCaBP and vitamin D-dependent CaBP participate at the outside and the inside of epithelial cell, respectively, to stimulate intestinal calcium absorption, and both CaBPs interact each other in calcium transport system. The mechanism of mCaBP action in the intestine is still unclear.
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