Abstract

The clinical management of breast cancer patients is guided by measures of tumor growth and metastatic potential (McGuire 1987). These clinical-pathological measures involve a number of parameters including the tumor size, histological type and grade, the presence of steroid receptors, and perhaps most importantly the status of the axillary lymph nodes (Simpson and Page 1992; Fisher 1992). The scope of this assessment is, however, significantly limited in patients with node-negative tumors and those with preinvasive lesions.

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