Abstract
Objective To analyze the influence of Bushen Tiaochong cycle therapy on Th1/Th2 deviation, sex hormone level, and pregnancy outcome of alloimmune recurrent spontaneous abortion (RSA). Methods From August 2018 to April 2020, 130 patients with alloimmune RSA who met the inclusion criteria were randomly divided into the control group (n = 65) and the study group (n = 65). The former received lymphocyte immunotherapy (LIT), and the latter received Bushen Tiaochong cycle therapy on the basis of LIT. The treatment ended at 12 w of pregnancy. The total score of traditional Chinese medicine (TCM) syndromes, Th1 cytokine (IL-2), Th2 cytokine (IL-10), and related hormones (chorionic gonadotropin (hCG) and progesterone (P)) were compared between the two groups before and after treatment. The positive rate of blocking antibody (BA), pregnancy success rate, and preterm birth rate were counted. Result After treatment, the total score of TCM syndromes, IL-2 level, and Th1/Th2 ratio in the two groups decreased significantly, while the levels of IL-10, hCG, and P increased significantly, and the study group improved significantly compared with the control group (P < 0.05). The positive rate of BA and pregnancy success rate in the study group were higher than those in the control group (P < 0.05). There was no significant difference in the preterm birth rate between the two groups (P > 0.05). Conclusion On the basis of routine western medicine treatment, a combined application of Bushen Tiaochong cycle therapy can significantly improve the Th1/Th2 deviation, serum sex hormone level, and pregnancy outcome in patients with alloimmune RSA.
Highlights
Recurrent spontaneous abortion (RSA) refers to the occurrence of two or more consecutive spontaneous abortions in pregnant women with same sexual partner before 24 weeks of pregnancy (28 weeks in China). e incidence is about 2∼4%, and the risk of recurrence increases with the increase in the number of abortions, causing serious harm to the physical and mental health of patients [1, 2]
The former has the highest incidence rate in RAS, accounting for 50%, which is related to the imbalance of maternal-fetal immune tolerance and is defined as unexplained RSA (URSA) [4, 5]. e latter is related to pregnant women’s autoimmune factors, which is the loss of pregnancy caused by autoimmune diseases [6]
From August 2018 to April 2020, 130 patients with alloimmune RSA who met the inclusion criteria were randomly divided into the control group (n 65) and the study group (n 65). ere was no statistical difference between the two groups in baseline information such as age, number of abortions, days of pregnancy, and risk factors (Table 1, P > 0.05). e two groups were comparable
Summary
Recurrent spontaneous abortion (RSA) refers to the occurrence of two or more consecutive spontaneous abortions (including consecutive biochemical pregnancies) in pregnant women with same sexual partner before 24 weeks of pregnancy (28 weeks in China). e incidence is about 2∼4%, and the risk of recurrence increases with the increase in the number of abortions, causing serious harm to the physical and mental health of patients [1, 2]. E incidence is about 2∼4%, and the risk of recurrence increases with the increase in the number of abortions, causing serious harm to the physical and mental health of patients [1, 2]. According to the maternal immunological factors of RSA, RSA can be divided into two types: alloimmune type and autoimmune type [3]. Among them, the former has the highest incidence rate in RAS, accounting for 50%, which is related to the imbalance of maternal-fetal immune tolerance and is defined as unexplained RSA (URSA) [4, 5]. Some studies believe that it cannot improve the live birth rate of Ursa patients, and the safety of blood products should be concerned [8]
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