Abstract
Zinc (Zn) and its alloys have received increasing attention as new alternative biodegradable metals. However, consensus has not been reached on the corrosion behaviour of Zn. As cardiovascular artery stent material, Zn is supposed to contact with plasma that contains inorganic salts and organic components. Protein is one of the most important constitute in the plasma and could adsorb on the material surface. In this paper, bovine serum albumin (BSA) was used as a typical protein. Influences of BSA on pure Zn corrosion in phosphate buffered saline is investigated as a function of BSA concentrations and immersion durations by electrochemical techniques and surface analysis. Results showed that pure Zn corrosion was progressively accelerated with BSA concentrations (ranging from 0.05 to 5 g L−1) at 0.5 h. With time evolves, formation of phosphates as corrosion product was delayed by BSA adsorption, especially at concentration of 2 g L−1. Within 48 h, the corrosion of pure Zn was alleviated by BSA at concentration of 0.1 g L−1, whereas the corrosion was enhanced after 168 h. Addition of 2 g L−1 BSA has opposite influence on the pure Zn corrosion. Furthermore, schematic corrosion behaviour at protein/Zn interfaces was proposed. This work encourages us to think more about the influence of protein on the material corrosion and helps us to better understand the corrosion behaviour of pure Zn.
Highlights
The polarization curves of pure Zn were obtained in phosphate buffer saline (PBS) with various bovine serum albumin (BSA) concentrations (0, 0.05, 0.1, 0.5, 1, 2, and 5 g L−1) after 0.5 h immersion
The Ecorr value of pure Zn is marginally lowered by addition of BSA compared to that in PBS-0, which indicates an enhancement of the sensitivity to corrosion of pure Zn
The icorr value progressively rises from 0.42 ± 0.03 μA cm−2 for PBS-0 to 7.65 ± 0.12 μA cm−2 when the BSA concentration increases to 5 g L−1
Summary
Zinc (Zn) and its alloys have received increasing attention as new alternative biodegradable metals, due to their biological merits [1,2,3,4,5,6,7,8] and ideal degradation behaviour [9,10,11,12,13]. Biocompatibility and mechanical integrity of implantations are often correlated to corrosion behaviour including corrosion rate and corrosion products [14]. Compared with biodegradable iron (Fe) and magnesium (Mg), Zn-based metals have moderate corrosion rates [15]. Numerous efforts were devoted to explore the corrosion mechanism of Zn alloys as biomaterials [17,18,19]. Consensus has not been reached since the corrosion behaviour of Zn is affected by
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