Abstract
It is shown that synthetic analogs of two bone marrow hexapeptides (myelopeptides 1 and 2), which are identical in structure to the N-terminal peptide fragments of hemoglobin α- and β-chains, are characterized by naloxone-independent antibody-stimulating activity. The antibody-stimulating effect of the myelopeptides becomes naloxone-dependent and stronger against the background of immunosuppression provoked by the hot plate test carried out before immunization. Intraperitoneal administration of both myelopeptides in doses of 10−13–10−8 g/mouse causes a naloxone-dependent modulatory effect on mouse algesthesia threshold with a predominant analgetic effect.
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