Abstract
The article describes modern points of view on processes of reparative regeneration at norm and in pathology, as well as on the effects, produced by different local and systemic agents on the course of fracture consolidation phases. Also, there are data of experimental studies, which demonstrate the positive effects of Bivalos on enlargement of calluses, improvement of biomechanical properties of bones and microarchitectonics of the osseous tissues, acceleration of fracture consolidation rates and implant osteointegration. The analysis of data of clinical observations revealed acceleration of fracture consolidation terms and improvement in the state of patients at different age owing to Bivalos. The article contains information about current randomized placebo-controlled studies of the role of Bivalos in patients after endoprosthesis replacement and in affection of bone fracture consolidation.
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