Abstract
Publisher Summary This chapter compares the effects of atropine, scopolamine, and benactyzine against the electroencephalogram (EEG) arousal evoked by physostigmine in rabbits. The effects of atropine, scopolamine and benactyzine on the EEG traces are qualitatively similar and they differed only in the intensity of their actions. It is established that the effect of scopolamine exceeded that of atropine more than ten times. Also, benactyzine proved to be about twice as effective as atropine. These ratios of the effects of these three drugs are also in good agreement with the results obtained in behavioral experiments or with different central pharmacological effects. If the ratio for the central and peripheral anticholinergic effects of atropine, scopolamine and benactyzine is evaluated the specificity of the central effect of scopolamine and especially that of benactyzine is evident.
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