Abstract
Objective To investigate the effect of Aspirin on the proliferation and NOS expression in astrocytoma cell line, and probe into its mechanism . Methods The effect of Aspirin on the growth of astrocytoma cells was evaluated by MTT assay; NOS protein levels were determined by immunohistochemistry, NO and CEA concentration in the medium were determined by Griess assay and lepton catch immunising method respectively.Results Aspirin can inhibit the growth of astrocytoma cells ,induce theexpressionofiNOS, increase the concentration of NO in the medium. The effect of these were in a concentration dependent pattern. Moreover,Aspirin can reduce the concentration of CEA in the medium. Conclusion Aspirin inhibit the growth of astrocytoma cell line . Up\|regulated iNOS expression resulting a increase of NO concentration are ascribed to mechanism of antiproliferation activity of Aspirin. CEA is a good indicator in monitoring curative effect of astrocytoma.
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