Abstract
Objective Evaluate anticoagulants influence on blood S100B levels. Design and methods Blood from 18 healthy adult subjects were collected using: no anticoagulants; EDTA; heparin; and citrate. S100B levels were determined using LIA-mat assay. Results Heparin and citrate increased S100B levels ( p < 0.001), whereas EDTA had no effect ( p = 0.24). Heparin samples were highly (r 2 = 0.97, p < 0.001), citrate samples were moderately (r 2 = 0.49, p < 0.001), and EDTA samples were not (r 2 = 0.22, p = 0.059) correlated with serum samples. Conclusion When anticoagulant is required, heparin should be the primary choice.
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