Influence of Anticholinesterase Diisopropylfluorophosphate on Cardiovascular and Respiratory Reflexes of Carotid Sinus Origin

Abstract

In previous investigations we were able to show that the anticholinesterase prostigmine has no effect on the central transmission of the carotid sinus pressoceptive reflexes acting on the cardio-inhibitory, vasomotor and respiratory centers.1 Recently O. Bodansky and A. Mazur2 reported on the very marked anticholinesterase activity on blood and tissues of diisopropylfluorophosphate (D.F.P.).The influence of the anticholinesterase D.F.P. on the respiratory, cardiac and the vasomotor reflexes induced by the carotid sinus presso-ceptors in the dog has been investigated.Method. In the dog, under choralosane anesthesia, the efferent arteries of the carotid sinus were ligated, care being taken not to sever the pressoceptive innervation. The cephalic end of the common carotid artery was connected with a pressure device. By means of this technic, the hydrostatic pressure may be increased or decreased in the isolated presso-sensitive innervated carotid sinus. The cardio-vascular and respiratory reactions of the an...