Abstract
The effects of antibiotics and surfactant addition on methionine accumulation in the broth culture of three strains of methionine yeilding Bacillus cereus (B. cereus DS-13, B. cereus AS-9 and B. cereus RS-16) recovered from different soil ecovars in Owerri Nigeria were investigated. Ampicillin and erythromycin neither stimulated growth nor enhanced methionine production in Bacillus cereus DS-13, while tetracycline and chloramphenicol stimulated growth and enhanced methionine yield in Bacillus cereus DS-13 and Bacillus cereus AS-9. Ampicllin had the highest stimulatory effect on growth and methionine production in Bacillus cereus RS 16. Tween 80 and palmitic acid stimulated growth and improved methionine accumulation in the broth culture of all Bacillus strains while stearic acid did not improve yield in all Bacillus strains.
Highlights
Methionine is an essential, economically important amino acid used as food and feed supplement
We reported the production of L-methionine by three methionine yielding strains of Bacillus cereus isolated from different soil ecovars in Owerri, Nigeria [12,13]
Studies on the effect of antibiotics on growth and methionine productivity shown in Figures 1-3, reveals that tetracycline and chloramphenicol at 0.05 and 0.1 μg/ml enhanced methionine productivity but did not stimulate
Summary
Methionine is an essential, economically important amino acid used as food and feed supplement. It is a precursor for the other sulfur amino acids, cysteine, taurine and glutathione, and plays an important role in human body by assisting in the breakdown of fats and preventing fat build up in the liver and arteries [1,2]. Methionine is essential for the absorption, transportation and availability of selenium and zinc in cellular functions It helps in the excretion of cadmium and mercury from the body. Most natural strains cannot produce industrially significant amounts of L-methionine in the culture broth due to various metabolic regulation mechanisms. Alteration of these mechanisms can lead to L-methionine accumulation [6,7]. The present study, seeks to investigate the effects of antibiotics and surfactant on methionine accumulation in the culture broth of the three newly isolated Bacillus cereus strains
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