Influence of anti anxiety and anti depression treatment on sudden hearing loss

Abstract

Objective:To study the influence of anti-anxiety and antidepression treatment on patients diagnosed as sudden hearing loss with anxiety and depression symptoms.Method:A prospective and controlled study was carried out. A total number of 248 patients with anxiety and depression symptoms were randomly divided into experimental group or control group by Stochastic tables law. A number of 126 patients in experimental group accepted anti anxiety and anti depression treatment, while 122 patients in control group did not accepted anti anxiety and anti depression treatment. The hearing and tinnitus effects were evaluated.SPSS 13.0 statistical software was used for data processing.Result:According to the results of pure-tone threshold audiometry, in the 126 cases of experimental group, 48 were cured (38.1%), 25 were markedly improved (19.8%), 23 were effective (18.3%), and 30 were invalid (23.8%).The total effective rate was 76.2% (96/126). In the 122 cases of control group, 34 were cured (27.9%),17 were markedly improved (13.9%),18 were effective (14.8%),and 53 were invalid (43.4%).The total effective rate was 56.6%(69/122).The two groups had no significant difference in recovery rates but it showed significant difference in total effective rates. Moreover, the total effective rate of the flat type of sudden hearing loss in experimental group was superior to that in control group, however there was no significant difference in total effective rates of other three types between two groups. The patients who had concomitant symptom of tinnitus in experimental group and control group accounted for 85.7% (108/126) and 84.4%(103/122), respectively. However, no significant difference was found in proportions of patients with tinnitus between the two groups. According to the tinnitus results, in the 108 cases of experimental group, 32 were cured (29.6%),19 were markedly improved (17.6%), 36 were effective (33.3%), and 21 were invalid (19.4%). The total effective rate was 80.6%(87/108). In the 103 cases of control group, 19 were cured (18.4%), 15 were markedly improved (14.6%),22 were effective(21.4%),and 47 were invalid (45.6%).The total effective rate was 54.4% (56/103).The two groups had no significant difference in recovery rates but it showed significant difference in total effective rates. There was no significant difference in total effective rate of the low-middle frequency sudden hearing loss between two groups, but the total effective rates of other three types in experimental group were all higher than those in control group.Conclusion:The total effective rates of hearing and tinnitus can be improved after combination treatment with anti-anxiety and anti-depression in sudden hearing loss patients with anxiety and depression symptoms. Moreover, different types of the hearing curves of sudden deafness have different improvement degrees.