Influence of androgen status on the quality of life in men suffering from coronary artery disease

Abstract

Introduction. Cardiovascular diseases, in particular, coronary artery disease, remain the leading cause of disability and mortality among the population in Ukraine and the world, which determines the urgency of finding new factors that can affect the quality of life of this population category. In particular, such factors may include androgenic status in men with coronary artery disease. Available literature data indicate a possible relationship between androgenic status and QOL in this population category, but further research is needed to study this issue in more detail.The purpose of the study: to determine the influence of androgen status on the quality of life in men suffering from coronary artery disease (CAD). Material and methods. 85 men with coronary artery disease aged 45-65 years participated in this prospective observational study. The selection of patients was carried out on the basis of the cardiology department. In addition to standard clinical and paraclinical examination methods, patients were assessed for their androgenic status by determining the level of total testosterone in the blood serum. When evaluating the quality of life level, a survey was conducted according to the WHOQOL-BREF questionnaire, which includes 4 sub-sections that determine respondents' satisfaction with their own physical and psychological health pit, environment and level of social interaction. After counting the points, a score from 4 to 20 was formed for each of the subdivisions. Then, statistical processing of the obtained results was carried out.Results and discussion. As a result of the study, a reliable positive correlation of medium strength was found between the level of testosterone and the satisfaction of the study participants with their own physical and psychological health, the Spearman rank correlation coefficient was 0.55 (p<0.05) and 0 .51 (p<0.05), respectively.Conclusion. It was concluded that a higher level of testosterone was associated with greater satisfaction with one's own physical and psychological health in men with coronary artery disease, which indicates the influence of androgen status on the quality of life in this category of patients.Prospects for further research. The obtained results indicate the need for further study of the relationship between androgen status and quality of life in men with coronary artery disease and the search for its possible mechanisms.