Abstract
In this investigation, an oral decongestant was compared with placebo for effects on Eustachian tube function in 13 children with chronic serous otitis media. Objective measurements of Eustachian tube function can be made in patients who have had pressure-equalizing tubes placed through their tympanic membranes to maintain long-term ventilation of the middle ear. In a double-blind crossover study design, 5 children definitely responded to the oral decongestant, 4 children showed no response, and 4 children had a suggestive response. None of the 13 patients responded to the placebo. The oral decongestant evaluated contained carbinoxamine maleate and pseudoephedrine hydrochloride. It is concluded this decongestant would benefit some children with chronic serous otitis media, particularly those with allergic rhinitis.
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