Abstract
Early anti-donor HLA specific antibodies (eDSA) impair graft survival after lung transplantation. Recently, patients with eDSA treated with an IgM-enriched human intravenous immunoglobulins-based protocol (eDSA/IVIG+ patients) have shown improved survival similar to eDSA- patients. However, the mechanisms remain elusive and not fully explained by DSA clearance. IVIG impact T regulatory cells (Tregs), whose increasing frequencies early (3 weeks) after transplantation are protective against chronic lung allograft rejection (CLAD). Aim of this study was to investigate Treg frequencies in eDSA/IVIG+ patients and compare them to Treg frequencies in eDSA- patients at 3 weeks, 3 and 6 months after transplantation.
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