Influence of an antibiotic drug neomycin sulphate on mixed micellization behavior of imidazolium based surface-active ionic liquids in aqueous media

Abstract

Imidazolium-based surface-active ionic liquids (SAILs) have unique physicochemical features that make them ideal for biomedical applications. Because SAILs have a higher surface activity than conventional surfactants, they can improve drug permeability across biomembranes, making them superior drug carriers than existing solutions. In-depth studies of interactions prevailing in mixed micellar system of SAILs in the presence of drug are required to fully exploit the promise of these materials in drug delivery applications. Thus, various thermodynamic, mixed micellar and surface-active properties of two imidazolium-based SAILs with different cationic structures i.e.1-dodecyl-3-ethylimidazolium bromide [C12eim][Br] and 1-dodecyl-3-butylimidazolium bromide [C12bim][Br] have been determined in water and 5 mM neomycin sulphate solution in aqueous media. The study has been conducted for different mole fractions of mixed micellar system of SAILs using conductivity and surface tension measurement techniques. Various theoretical models such as Clint, Rubingh, Motomura and Rodenas models have been applied to understand the interactions prevailing in the mixed [C12eim][Br] /[C12bim][Br] system in water and neomycin sulphate solution in aqueous media.