Abstract
Pellets were prepared by extrusion spheronisation using microcrystalline cellulose as pellet forming agent and two drugs with different solubility, theophylline monohydrate and sulfamethoxazole. Different amounts of water were used for the granulation step prior to extrusion spheronisation. The amount of granulating fluid used had an influence on the drug release from the pellets. A slower release rate was observed with increasing amounts of granulating fluid. These differences in the release profiles were correlated with differences in hardness, density and structure of the pellets.
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