Abstract
SummaryAdrenal enlargement, nephrosclerosis and hypertension were produced by a lyophylized anterior pituitary (LAP) preparation in rats kept on a synthetic diet containing no protein, but an adequate amount of amino-acids. The severity of the lesions was less marked, however, than in rats receiving an equivalent amount of nitrogen in the form of a casein-hydrolysate. It appears that amino-acids suffice to sensitize the organism to the production of hypertensive disease by LAP. This is noteworthy since no such pathologic changes can be produced by LAP on other diets deficient in proteins.
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