Influence of amino acid imbalance in maternal and fetal organisms on the development of placental insufficiency and the course of the neonatal period.

Abstract

The content of amino acids in maternal serum and umbilical cord blood during physiological pregnancy and placental insufficiency (PI) was estimated using ion-exchange chromatography. It was found that that the content of arginine, serine, glutamine, alanine, cysteine, methionine, tryptophan, leucine, phenylalanine and proline, which are involved in many metabolic processes necessary to maintain the normal functioning of the mother-placenta-fetus system, was decreases in maternal serum at PI. Opposite deviations have dicarboxylic amino acids, lysine, histidine, glycine, tyrosine and threonine, the number of which increases, strengthening the nitrogen imbalance. In the blood serum of the umbilical cord for most amino acids, was a similar direction of changes, but the degree of it is more pronounced. The opposite direction of changes is found for glycine, threonine, tyrosine, the content of which is reduced. The results of the study make it possible to broaden the understanding of the mechanisms of PI development and to offer informative tests for predicting the state of newborns.