Abstract
Because thermoregulation and food consumption are interrelated, and because thermoregulation processes are influenced by ambient temperature, we examined the effects of neuropeptide Y (NPY) on both body temperature and food intake in various thermal environments after intracerebroventricular administration of 20 μg. Results reveal that the prominent effects of NPY on body temperature and food intake in relatively thermoneutral environments are drastically altered at more extreme ambient temperatures. NPY produced hypothermia in animals placed at 4, 12, and 21 °C, and actually increased body temperature in animals subjected to 30 and 38 °C temperature. On the other hand, in comparaison with ambient temperatures of 12 and 21 °C, ambient temperatures of 4 and 30 °C significantly reduced the stimulatory effect of NPY on food consumption. Moreover, at 38 °C the effect of NPY on food intake was totally abolished. These data demonstrate that ambient temperature has a critical influence on central actions of NPY.
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