Abstract
The effect of added Alzheimer's Aβ(1-40) peptide of the wild type on the lateral diffusion of lipids in macroscopically oriented bilayers of ‘raft’ compositions [a mixture of dioleoylphosphatidylcholine (DOPC), sphingomyelin (SM) and cholesterol (CHOL)] was studied by an NMR-diffusion technique. In homogeneous bilayers, diffusion coefficients decrease, while they change differently in liquid ordered and in liquid disordered phases at varied concentrations of CHOL; this was explained by the decreased maximum solubility of CHOL in phospholipids in the presence of Aβ(1-40) peptide.
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