Abstract
The present study was designed to understand the cigarette smoking-induced alterations in hormones and the resulting changes in platelet serotonin (5-hydroxytryptamine, 5-HT) and monoamine oxidase (MAO-B) activity in chronic smokers. Human male volunteers aged 35±8years, were divided into two groups, namely controls and smokers (12±2 cigarettes per day for 7-10years). Results showed that cigarette smoking significantly (p<0.05) elevated plasma triiodothyronine (T3), cortisol and testosterone levels with significant (p<0.05) reduction in plasma tryptophan and thyroxin (T4). Moreover, smokers showed reduced platelet 5-HT levels and MAO-B activity. In smokers, plasma cortisol was negatively correlated with tryptophan (r=-0.386), platelet MAO-B (r=-0.264), and 5-HT (r=-0.671), and positively correlated with testosterone (r=0.428). However, testosterone was negatively correlated with platelet MAO-B (r=-0.315), and 5-HT (r=-.419) in smokers. Further, smokers plasma T3 levels were negatively correlated with platelet MAO-B (r=-0.398), and 5-HT (r=-0.541), whereas T4 levels were positively correlated with platelet MAO-B (r=0.369), and 5-HT (r=0.454). In conclusion, our study showed that altered testosterone and cortisol levels may aggravate behavior, mood disturbances and symptoms of depression by decreasing platelet 5-HT and MAO-B activity in smokers.
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