Abstract
In this particular study, the objective was to examine how varying doses of gliclazide (1 mg kg-1) and Allium sativum (104 mg kg-1) affect interaction in rats with diabetes induced by alloxan. The diabetes was induced by intraperitoneal injection of alloxan at a dosage of 100 mg kg-1 of body weight. The results revealed that the administration of gliclazide at 1 mg kg-1 of body weight and A. sativum at 104 mg kg-1 body weight exhibited noteworthy antihyperglycemic effects. The objective was to determine whether an interaction exists between these two substances in the context of diabetic conditions. In combination the A. sativum significantly enhanced the antihyperglycaemic activity of gliclazide from 2nd to 8th h except at 4th h. Hence, there is existence of pharmacodynamic interaction between A. sativum and gliclazide.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
