Abstract
The effects of alkali metal cations on the rates at which Ca 2+ and phosphatidic acid were cotransported from aqueous to hydrocarbon medium were examined. The alkali metal cations remained in the aqueous phase yet specifically influenced the transport of Ca 2+ into the hydrocarbon solvent. For the physiological cations, Na + and K +, there were critical concentration ranges in which small changes in concentration effected sharp changes in transport rates. The maximal rate observed with Na + was an order of magnitude greater than that with K +; however, unlike Na +, K + promoted low levels of transport below the critical concentration range. Li + effected only low levels of transport even at high concentrations, whereas Rb + and Cs + induced transport at rates proportional to their concentrations. These results are discussed in terms of a classical ionophore model for the complex composed of a neutral phosphatidic acid dimer bridged by Ca 2+.
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