Abstract
Aim. The aim of the study was to state the peculiarities of changes in patients with rheumatoid arthritis (RA) depending on blood ALD. Materials and methods. Thirty four patients with diagnosed RA were divided into two groups depending on blood aldosterone (ALD) level (determined with IEA method): group I included 16 patients with ALD level ≤ 130 pg/ml, group II - 18 patients with ALD level > 130 pg/ml. To carry out semiquantitative microdetermination of synovial membrane (SM), patients underwent knee joint arthroscopy followed by biopsy. Results. In patients of group II, it was stated as a result of morphological study that SM tectorial cells proliferation > 6 rows occurred by 35 % more often, villous hyperplasia and SM edema - by two times more often versus group I ( p < 0,05). Direct correlation between blood ALD level and the following microdetermination indices in RA patients was established: villous hyperplasia with tectorial cells proliferation, formation of lymphoid follicles, mycoid swelling and fibrinoid changes. Conclusions. High ALD level can be considered as proliferative-destructive activity marker in patients with rheumatoid arthritis.
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