Abstract

目的 研究静脉输注白蛋白对重度高胆红素血症换血患儿胆红素换出率的影响.方法 对47例临床达换血标准的患儿随机分为2组进行换血治疗,治疗组22例,换血前1 h予白蛋白1 g/kg静脉输注,对照组25例换血前不予白蛋白.两组换血方法 、步骤、换血量、换血前后各项监护均相同.比较两组换血前、中(换血总量的一半)、后血清胆红素的换出率.结果 治疗组总胆红素与未结合胆红素在换血中、换血后的换出率分别是36.4%、51.0%,37.1%、49.1%;对照组总胆红素与未结合胆红素在换血中、换血后的换出率分别是35.9%、48.9%,37.3%、51.5%;两组间血清胆红素的换出率差异无显著性(P>0.05).两组换血中和换血后血清胆红素水平与换血前比较差异有非常显著性(P<0.01).结论 静脉输注白蛋白对高胆红素血症患儿血清胆红素换出率没有影响,并造成资源浪费。

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