Abstract

Two population-based studies recently identified a high prevalence of unexplained thrombocytopenia, especially in men and older people (Biino et al , 2011; Santimone et al , 2011). Moreover, these studies reported a wide variability in the prevalence of thrombocytopenia in different villages. Further investigation concluded that the development of thrombocytopenia derived from the interaction of three factors: genetic factors, which set the ‘basic’ platelet count, gender-related factors, which result in lower platelet count in men and age-related factors, which are responsible for a progressive decrease in the platelet count over a life-time (Biino et al , 2011).

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