Abstract
Sleep plays a crucial role in maintaining brain function and neuronal signalling and helps maintain overall health of the individuals. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. The aim of the present study was to investigate the SD induced oxidative stress with advancing age in different brain regions. In the present study, young and old rats were taken as control and experimental rats (n=6) respectively. Lipid peroxidation and protein oxidation significantly increased (p<0.05) and reduces antioxidant levels in experimental young and old rats. The most affected part of the brain was hippocampus followed by cerebral cortex. The biochemical changes observed in SD treated young rats were comparable to those of untreated old control rats. Therefore, SD may play a role in the premature aging of animals.
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