Abstract
Overnight-fasted rats ranging in age from 8 to 104 days were stressed by centrifugation for 2.5 or 5.0 hr at 4.7 g. Liver glycogen, plasma corticosterone, liver glycogen synthetase and plasma glucose were determined in stressed rats as a function of age and compared to noncentrifuged control rats. Significant increases in liver glycogen deposition occurred in centrifuged rats 18 days or older but not in younger rats. The unresponsiveness of the younger rats was attributed to their limited ability to elaborate increased amounts of adrenal corticosterone during centrifugation. Liver glycogen synthetase was increased significantly by centrifugation in selected groups of the older animals. An increase in synthetase was not a necessary step in the observed increase in liver glycogenesis in centrifuged rats. Glucose or corticosterone, either alone or in combination, administered to normal unstressed rats had no significant effect on liver glycogen synthetase activity. (Endocrinology 78: 556, 1966)
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