Abstract
Ten μg/ml of adriamycin produces a significant decrease in peak tension of isolated guinea pig atria without modification of cellular Ca content. The analysis of the curve of Ca exchanges shows that adriamycin significantly reduces the calcium exchangeable fraction, whereby the Ca fast exchanging compartment is suppressed and the slow exchanging one is slightly increased. Ouabain prevents the negative inotropic effect of adriamycin and restores the rapid Ca compartment without significantly modifying either the cellular Ca content or the amount of calcium exchangeable fraction. These results demonstrate that calcium plays a role in the negative inotropic effect of adriamycin in cardiac muscle and confirm the importance of the fast exchanging fraction in regulating the contractile force of the heart.
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