Abstract
The central effects of angiotensin in unanes thetized rats were studied before and after administration of adrenergic blocking drugs. Intraventricular injections of prevented angiotensin-induced drinking, sympathetic stimulation, and vasopressin release. Administration Phentolamine of various β-adrenergic blocking drugs, either intraarterially or intraventricularly, did not alter central angiotensin activity in a manner which could be correlated with β-adrenergic blockade. Local anesthetics inhibited central angiotensin pressor and drinking effects. Centrally administered phentolamine or tetracaine appear to be useful tools for further studies of the actions of angiotensin on the central nervous system.
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