Abstract
The higher level of ketonuria during fasting in women than in men was first noted by Deuel and Gulick (1). Butts and Deuel (2) have found that an artificial ketonuria, produced by administration of sodium acetoacetate to rats, also showed similar sex differences. The discovery by Burn and Ling (3, 5) and others (4) that preparations of the anterior pituitary gland have the ability to produce a ketonuria in fasting rats that otherwise have no measurable quantity of ketone bodies led Butts et al (6) to consider the possibility that the sex difference in ketosis rested in the activity of the pituitary gland. It has been found (7, 8, 9) that the ketosis due to APE is greatly reduced or abolished following the removal of the adrenal glands. Furthermore, the fasting ketosis of pregnancy (9), which might well be related to anterior pituitary activity, is abolished by adrenalectomy. It would seem possible that if the sex difference in ketosis was a function of the anterior pituitary it might disappear when the ad...
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