Abstract
IN RECENT YEARS it has been demonstrated that long continued administration of desoxycorticosterone acetate (DCA) may induce a rise in blood pressure in patients with or without disease of the adrenal glands (Loeb, Atchley, Ferrebee and Ragan, 1939; Ferrebee, Ragan, Atchley and Loeb, 1939; Thorn, Dorrance and Day, 1942; Engel, Cohn and Soffer, 1942; Roth, Robinson and Wilder, 1943; Perera, Knowlton, Lowell and Loeb, 1944) as well as in normal dogs and rats (Kuhlmann, Ragan, Ferrebee, Atchley and Loeb, 1939; Grollman, Harrison and Williams, 1940; Selye, Hall and Rowley, 1943). In animals treated with DCA, this hypertension is often associated with evidences of renal damage (Selye, Hall and Rowley, 1943; Selye and Hall, 1943; Selye and Pentz, 1943). No similar effect on blood pressure has been reported following prolonged treatment with adrenal cortical extract (ACE), Grollman, Harrison and Williams (1940).
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