Abstract
AbstractTheophylline suppositories were made by the fusion method, using a polyethylene glycol base. Formulations were prepared containing theophylline in the plain base, and in base with added sodium salicylate or lecithin-sodium deoxycholate as adjuvants. Changes in melting range over time were studied. Differential scanning calorimetry studies characterized the physical nature of the formulations as being brittle or elastic. These data were confirmed by concurrently measuring the initial slope of stress -strain curves obtained at constant strain rate during hardness determination. Release rates were determined with a modified dissolution basket containing glass beads and dialyzing membrane. It was found that drug release rate from plain suppository base > base containing lecithin-sodium deoxycholate > base with sodium salicylate. In vivo bioavailability of theophylline after rectal administration in rabbits showed that rectal absorption was not enhanced in the presence of adjuvants, and theophylline wa...
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