Abstract
The relationship between obesity and prostate cancer aggressiveness is controversial in recent studies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness. A total of 184 patients who underwent radical retropubic prostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels of adipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0. The PF rates showed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue was distributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed a statistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). The levels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer, and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67, P<0.001). No association was observed between adipocytokines and BMI. Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF and CRP have promoting effects on progression of prostate cancer.
Highlights
Prostate cancer is the second most common malignant tumor of men worldwide, the incidence of which has risen gradually in China during recent decades (Jemal et al, 2011; Tang et al, 2013)
The body mass index (BMI) doesn’t effectively reflect the most metabolic fat active in body; The visceral adipose is a more sophisticated measure of abdominal obesity than BMI, because it is metabolic active and can produces a large number hormones and cytokines, including tumor necrosis factor-α, interleukin-6, leptin and C-reactive protein (CRP), which showed a close association with the promotion and progression of prostate cancer (Vol Hafe et al, 2004; Mistry et al, 2007; Mucksavage et al, 2012)
The aim of our study is to evaluate correlation of prostate cancer aggressiveness with obesity by measuring the visceral fat on magnatic resonance imaging (MRI), and to investigate the role of adipocytokines in stimulating the promotion and progression of prostate cancer
Summary
Prostate cancer is the second most common malignant tumor of men worldwide, the incidence of which has risen gradually in China during recent decades (Jemal et al, 2011; Tang et al, 2013). The body mass index (BMI) doesn’t effectively reflect the most metabolic fat active in body; The visceral adipose is a more sophisticated measure of abdominal obesity than BMI, because it is metabolic active and can produces a large number hormones and cytokines, including tumor necrosis factor-α, interleukin-6, leptin and C-reactive protein (CRP), which showed a close association with the promotion and progression of prostate cancer (Vol Hafe et al, 2004; Mistry et al, 2007; Mucksavage et al, 2012). The aim of our study is to evaluate correlation of prostate cancer aggressiveness with obesity by measuring the visceral fat (periprostatic fat) on MRI, and to investigate the role of adipocytokines in stimulating the promotion and progression of prostate cancer. IL-6, PF and CRP have promoting effects on progression of prostate cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
