Abstract
Investigation of the effect of adding carrier fines to the wet decanted carriers and the subsequent effects on the in vitro deposition of salbutamol sulphate. Methods: The wet decantation process used to remove the surface carrier fines carried out nine time for lactose and mannitol carriers. Addition lactose fines up to 8% to decanted lactose. Additionally, mannitol fines up to 16% were added to decanted mannitol. In vitro deposition carried out for those treated carriers after mixing with salbutamol sulphate using the NGI. Results: There were significant increase in fine particle fraction (FPFs). This probably by reducing drug-carrier adhesion and allowing easy detachment of the drugs from the carrier surface. Although this addition of fines could not revert the FPFS to the original value of the untreated carriers. Conclusions: Addition of micronized carriers to decanted carriers found to increase significantly the dispersion of the drug and the in vitro deposition.
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