Influence of ABO Blood Group on Fibrinogen Levels and Platelet Count in Apparently Healthy Nigerian Subjects

Co Okeke,Vc Iloka

doi:10.23937/2469-5696/1410054

Abstract

A total of hundred (100) apparently healthy young adult male and female participants comprised of 25 subjects of blood group A, B, AB and O respectively were recruited for this study. Five milliliters of blood was collected and used for the estimation of fibrinogen levels, platelet count and ABO blood grouping using standard laboratory methods. Statistical package for social science (SPSS) version 20 was employed in the analysis of the data.

Highlights

Introduction clinical significance ofABO blood type extends beyond transfusion medicine and solid organ/hematopoietic transplantation
Blood group O individuals may be more predisposed to thrombocytopenia than blood group A individuals
The present study evaluated the fibrinogen levels and platelet count in subjects of different ABO blood groups with the view of ascertaining if disparity exists in the levels of platelets and fibrinogen amongst the different ABO blood groups as this may provide possible explanation for previous findings especially in ABO differential disposition to thrombotic disorders

Summary

Introduction

Introduction clinical significance ofABO blood type extends beyond transfusion medicine and solid organ/hematopoietic transplantation. The ABO blood group is determined by the presence of A and B antigens on the surface of the red blood cells (RBCs). A close relationship exists between ABO blood type and the risk of venous thromboembolism [5,6]. In both arterial and venous thromboembolism, non-O (A, B, or AB) individuals show significantly increased risk [7,8], whereas group O individuals have more pronounced inherited bleeding tendency [9]. A close association has been shown to exist between ABO blood type and the risk of some diseases with non-O (A, B, or AB) individuals having an increased differential disposition to thrombotic disorders

Methods

Results

Discussion

Conclusion