Abstract
The apparent effect of ethyl chlorophenoxyisobutyrate (CPIB) on serum and tissue lipids of rats was markedly influenced by a terminal period of fasting and/or discontinuation of the drug. The significant reduction of serum triglycerides, cholesterol, and phospholipid observed during CPIB administration was no longer present 18 to 24 hours after withdrawal of the drug. The increase in liver triglycerides during CPIB administration was reversed after 24 hours withholding of both food and drug, liver triglycerides then being lower than in fasted control animals.
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