Abstract
ABSTRACT When submitting adult obese subjects to a low-calorie diet (800–1000 kcal/day), there is an important reduction in the urinary excretion of dehydroepiandrosterone (DHA); urinary androsterone also showed a tendency to decrease, whereas the changes in urinary etiocholanolone were less uniform. Total food withdrawal resulted in an almost complete disappearance of DHA sulfate, androsterone sulfate, etiocholanolone sulfate and other solvolyzable conjugates from the urine with the exception of a compound tentatively identified as androst-5-ene-3β,16a,17β-triol sulfate, of which the excretion was less markedly reduced. At the seventh day of the fast, the excretion of the glucuronides of androsterone and etiocholanolone had diminished by 61.3 and 52.9%, respectively. On the other hand, plasma levels of DHA sulfate and androsterone sulfate were higher on the seventh day of the fast than during the period of usual food intake. During fasting, urinary DHA remained low when administering DHA perorally or DHA...
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