Abstract
The addition of chlorhexidine (CHX) to a resinous experimental Mineral Trioxide Aggregate (E-MTA) based root-end filling material is an alternative to boost its antimicrobial activity. However, the influence of chlorhexidine on the properties of this material is unclear. The aim of this study was to evaluate the influence of 2% chlorhexidine on the pH, calcium ion release and setting time of a Bisphenol A Ethoxylate Dimethacrylate/Mineral Trioxide Aggregate (Bis-EMA/MTA) based dual-cure experimental root-end filling material (E-MTA), in comparison with E-MTA without the addition of CHX and with conventional white MTA (W-MTA). The materials were placed in polyethylene tubes, and immersed in deionized water to determine pH (digital pH meter) and calcium ion release (atomic absorption spectrometry technique). The setting time of each material was analyzed using Gilmore needles. The data were statistically analyzed at a significance level of 5%. E-MTA + CHX showed an alkaline pH in the 3 h period of evaluation, the alkalinity of which decreased but remained as such for 15 days. The pH of E-MTA + CHX was higher than the other two materials after 7 days, and lower after 30 days (p < 0.05). All of the materials were found to release calcium ions throughout the 30 days of the study. The addition of CHX increased the calcium ion release of E-MTA to levels statistically similar to W-MTA. E-MTA showed shorter initial and final setting time, compared with W-MTA (p < 0.05). The addition of 2% CHX to MTA prevented setting of the material. The addition of CHX to E-MTA increased its pH and calcium ion release. However, it also prevented setting of the material.
Highlights
Periapical surgery usually consists of root-end resection and root-end filling to seal the communication between the apical tissues and the root canal system.[1]
white Mineral Trioxide Aggregate (MTA) (W-MTA) showed an alkaline pH during the 30 days of the experiment
end filling material (E-MTA) + CHX showed an alkaline pH in the 3 h evaluation period; the level decreased, it remained alkaline for 15 days
Summary
Periapical surgery usually consists of root-end resection and root-end filling to seal the communication between the apical tissues and the root canal system.[1] Root-end filling materials should prevent leakage, promote antimicrobial activity, and provide an effective environment for healing of the apical tissues.[2,3] Mineral Trioxide Aggregate (MTA) as a root-end filling material has proved to be the most effective material in preventing leakage[3] and stimulating tissue repair.[4]. Inf luence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material. The extended setting time of MTA may cause the material to be washed out of the cavity during root-end surgery. The addition of light-curable resinous monomers to MTA has been proposed to improve its properties and reduce its setting time.[10] this addition to MTA cements inhibits MTA calcium ion release, impairing its ability to stimulate tissue repair.[11,12]
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