Abstract
In a preliminary study 1 mg per day of 2-Br-a-ergocryptine (CB-154) was shown to be effective in reducing serum levels of prolactin. In a second experiment 1 mg CB-154 was injected twice daily for 20 days, which included one complete estrous cycle, into 5 ewes. Serum levels of luteinizing hormone, follicle-stimulating hormone and progesterone were not different between CB-154-injected and control ewes. Prolactin levels were reduced to <0.5 ng⁄ml in CB-154-treated ewes throughout the treatment period. Prolactin levels ranged from 10 to 100 ng⁄ml in control ewes. It was concluded that luteal function as judged by regression of marked corpora lutea, estrous cycle length, or serum levels of progesterone was not different between CB-154- treated and control ewes. These data suggest that: 1) very low levels of prolactin are adequate to insure normal luteal function; or 2) prolactin does not play a role in the regulation of luteal function in normal cycling sheep. (Endocrinology 94: 612, 1974)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
