Abstract
Tumor initiation in CD-1 mice by benzo[ a]pyrene (BaP) or N-methyl- N′-nitro- N-nitrosoguanidine (MNNG) was unaffected by topical pretreatment with 13- cis-retinoic acid (13- cis-RA). Likewise, anthralin-induced tumor promotion in SENCAR mice was unaffected by pretreatment with 13- cis-RA. These results suggest that the action of retinoids in preventing either tumor initiation or promotion is very carcinogen or cocarcinogen specific.
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