Abstract
The effect of 13-cis retinoic acid (Ro-4-3780) on zymosan-induced chemiluminescence (CL) of freshly drawn human blood and isolated granulocytes has been examined in vitro. A marked enhancement was observed; optimal concentrations were 100 μg/ml in whole blood CL and 10 μg/ml in isolated granulocyte CL. It was found that already 5 μg/ml of 13-cis retinoic acid in isolated granulocytes showed a significant enhancement in zymosan-induced CL. The enhancement by 13-cis retinoic acid was completely inhibited by 10-5 M sodium azide, which is an inhibitor of myeloperoxidase activity. CL response was not enhanced by retinoic acid in mouse bone marrow originated cultured macrophages, which do not have myeloperoxidase activity. These findings strongly suggest that 13-cis retinoic acid might stimulate myeloperoxidase-dependent CL.
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