Abstract
Male newts, Cynops pyrrhogaster, were injected daily intraperitoneally either with vehicle (50 μl of 0.9% NaCl containing 0.1% ethanol/10 g body wt) or 1,25(OH)2D3 (0.1 μg/10 g body wt) for 10 days. The blood samples were collected on days 1, 3, 5, and 10 after initiation of the experiment, and plasma calcium and phosphate levels were analysed. In 1,25(OH)2D3-injected newts there was a progressive hypercalcemia from day 1 to day 3. On day 5 and day 10 the levels were not significantly different from vehicle-injected newts. The plasma phosphate levels increased from day 3 to day 5. On day 10 the levels became almost normal. To the best of our knowledge the present study is the first report from urodeles clearly indicating a true calcium and phosphate regulatory role of the vitamin D3 endocrine system and 1,25(OH)2D3 as a biologically active calcium and phosphate-regulating hormone in this group of vertebrates. J. Exp. Zool. 284:23–26, 1999. © 1999 Wiley-Liss, Inc.
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