Abstract
Subcutaneous administration of graded doses of neuropeptides related to lipotropin (βLPH) changed responsiveness of rats to electric footschock. γ-Endorphin and related peptides increased the susceptibility of rats, whereas β-endorphin induced a reversed effect. The enhanced responsiveness induced by DTγE, persisted for more than 24 hr and appeared to be of a central origin. Structure-activity relationship studies revealed that the sequence LPH 65–69 may contain the active core in this respect. An increased sensitivity to electric shock within one test procedure was observed with DTγE and α-endorphin. Prior experience with the test procedure diminished or abolished this effect of α-endorphin. It is suggested that β-endorphin and its fragments play a physiological role in adaptive behavioral changes induced by peripheral stimuli.
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