Influence and Effect of Acupoint Application of Chinese Medicine on Height and Bone Age of Children with Short Stature.

Weiqun Wang,Zhengyang Shao,Yuping Xiao,Hong Sun,Yushuang Ye,Songwen Tan

doi:10.1155/2021/7459593

Abstract

Objective To explore the effect of acupoint application of Chinese medicine on children's height and bone age. Methods Altogether, 120 children with a short stature treated in our hospital from September 2017 to September 2018 were divided into the control group (CG, n = 60) and the observation group (OG, n = 60) according to the random number table method. The children in CG were given healthy diet and exercise plans and supplemented with daily vitamin intake. The OG was treated with acupoint application of Chinese medicine on the basis of the CG. The clinical efficacy of the CG and the OG of children after treatment was observed. The height increment, growth rate, and bone age of children were compared before and after treatment. The levels of IGF-1 and 25-(OH)D in the serum of children before and after treatment were tested. According to the clinical curative effect after treatment, the children were divided into good curative effect group (markedly effective + effective) and poor curative effect group (ineffective). Logistics regression analysis was applied to analyze the risk factors. Results Compared with the CG, the curative effect on the OG was evidently improved (P < 0.05). In addition, the height increment, the growth speed, and the bone age of the OG increased evidently (P < 0.05). Compared with the CG, the expression of IGF-1 and 25-(OH)D of the OG elevated (P < 0.05). Serum IGF-1 and 25-(OH)D concentrations were positively correlated with growth rate and bone age (P < 0.05). Risk factors analysis showed that disease course, IGF-1, 25-(OH)D expression, and heredity were the risk factors affecting the curative effect on children. Conclusion Acupoint application of Chinese medicine has effect on the height and bone age of children with short stature, which is worthy of clinical promotion. In addition, early treatment should be carried out to improve the clinical efficacy of children.

Highlights

With the improvement of living standards, many families pay more attention to children’s growth and development nowadays
Further reviewing the treatment protocols, we found that, guided by the theory of traditional Chinese medicine evidence-based treatment, the disease is treated with external treatments of traditional Chinese medicine such as acupoint application of Chinese medicine, where the prepared Chinese medicine is applied to the patient’s skin, meridians, or acupoints, which is expected to achieve the purpose of unblocking meridians, harmonizing qi and blood, and promoting growth
Rank sum was applied for the grade data test, and logistic regression was applied to test the risk factors affecting the curative effect on children. e clinical value of risk factors was evaluated with the receiver operating curve (ROC). e Pearson test was used to analyze the correlation of IGF-1 and 25-(OH)D concentrations with growth rate and bone age

Summary

Introduction

With the improvement of living standards, many families pay more attention to children’s growth and development nowadays. In the growth and development clinic, more than 50% of the children seek medical advice because of their short stature [1]. Children with short stature refers to those whose height is lower than the average height of the normal children of the same race, sex, and age in a similar living environment by two standard deviations (−2SD) or by the third percentile (−1.88SD) [2]. Many disorders can cause short stature, including growth hormone (GH) deficiency, hypothyroidism, less than gestational age chromosome diseases, hypophysial hormone deficiency, idiopathic short stature (ISS), familial short stature, constitutional delay of puberty, malnutrition, and precocious puberty [3]. The incidence rate of ISS has been increasing year by year but the clinical treatment rate is rarely improved. The incidence rate of ISS has been increasing year by year but the clinical treatment rate is rarely improved. ere is an urgent need for a timely, safe, and convenient treatment method in clinical practice

Methods

Results

Conclusion