Infliximab Management Complex Regional Pain Syndrome

Abstract

The role of inflammatory mechanisms in the pathogenesis of CRPS is important and that makes it a target that must meet every day. Infliximab is a molecule that has been used in the management of CRPS and published case reports and two studies showing improvement in range of motion, differences in temperature and decrease pain persist even phenomena of peripheral and Central after a few months; as same adverse reactions have been reported including appearance of CRPS in patients who received other necessary conditions and use with caution. The information is so far low level of evidence for such studies from which it was generated so it is necessary to have higher quality studies to obtain more solid conclusions. Summary The complex regional pain syndrome (CRPS) is a variety of painful conditions of regional finding, after an injury, with distal predominance with symptoms that exceed in magnitude and duration the expected clinical course, with motor impairment and progressive course. Within the pathophysiology of complex regional pain syndrome multiple factors that produce and therefore proposed treatments are evaluated current evidence is recognized. One mechanism proposed that may contribute to the occurrence of CRPS is a tumor necrosis factor, TNFa, and a therapeutic proposal is the use of monoclonal antibody TNFa inhibitor, infliximab. The aim is to review aspects of diagnosis, pathophysiology and current evidence on the use of infliximab in CRPS.