Abstract
We report a patient with fistulizing Crohn’s disease who developed bacterial endophthalmitis following a single infusion of infliximab. A 26-year-old lady presented with recurrent bloody diarrhea and perianal discharge since 2 years. She had undergone incision and drainage for a perianal abscess 9 months ago with no improvement. She had also received prednisolone and 5-aminosalicylic acid with no benefit. When she presented to us, she had episodes of bloody diarrhea and persistent perianal symptoms. Examination revealed multiple abscesses in perianal area with extensive cellulitis, and edematous left labia majora. She had leucocytosis and hypoproteinemia; liver function tests, renal function tests, chest skiagram and barium meal follow through were unremarkable. Pus culture grew Streptococcus hemolyticus. Colonoscopy showed multiple perianal sinuses, congested and edematous anal canal with aphthoid ulcers, areas of frank ulceration and mucosal bridging in sigmoid, descending and transverse colon. Histopathology from perianal area showed granulomatous inflammation consistent with Crohn’s disease; colonic biopsies showed chronic inflammation. During drainage of perianal abscesses
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