Inflammatory Thyroid Changes Following Serotonin Receptor Blocking in Experimental Rats

Abstract

According to studies, a pathophysiological feature of schizophrenia may be a dysregulation of the inflammatory immune response. Conversely, antipsychotic medications have been found to have an immunosuppressive effect in patients with schizophrenia; however, this has not been consistently observed in different studies. The purpose of the following study is to compare the effects of risperidone with aripiprazole on thyroid function as it relates to inflammatory markers (CRP). This study was based on a randomized controlled trial. A total of thirty rats were recruited for the experiment and were kept in the artificial, and optimal environment. The rats were divided into three groups; each group has an equal number of rats which was 10 rats each. The first group was the control group which received the placebo, in the second group, there were 10 rats too, which was known as the risperidone group. Each rat received 20mg/kg/day through I/V. The third group is known as the aripiprazole group which received the drug from the intravenous route, 10mg/kg//day. In the results, the summarized values represented that all the mean values before and after the treatment remained less than 3.0. From the results and other evidence, it can be said that although the subjects who receive the following results do not require regular or frequent monitoring of thyroid hormones in long-term use and in the use of the drug in higher concentration there must be a check as long term use is associated with hyperthyroidism.